Improving the solubility and changing the dissolution rate of the poorly soluble active pharmaceutical ingredients (API’s) AMG 517, glipizide, and naproxen through the preparation of eutectic mixtures was investigated. Mixtures of the API’s with other small molecules were prepared to construct a phase diagram used to identify the eutectic mixture compositions. The search for a eutectic mixture ...

objective(s):drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. analgesics such as nsaids have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. meloxicam is one of nsaids with no topical form in the market. in this research, we attempted to quantify the skin permeation of a m...

Zirconium Diboride (ZrB2) powder was synthesized at low temperature via a Direct Molten Salt Reaction (DMSR) method. The influence of different salt compositions including eutectic mixture of (KF-NaF), (KF-KCl) and (KCl-NaCl) on the morphology and purity of the reaction products was studied. The obtained samples were characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD...

The stability of the eutectic carbide in a self-designed Fe-Cr-Mo-W-V-C alloy during solidifi atio as a alyzed i this ork. The ar ide pre ipitatio rule of the steel was calculated by Thermo-Calc.The typical microstructures at 1240 °C and 1200 °C ere o ser ed y opti al i ros ope OM ,field e issio s a i g ele tro microscope (FESEM) and transmission electron microscope (TEM). The selected area dif...

We discuss the use of nuclear magnetic resonance (NMR) spectroscopy to investigate the physical state of the eutectic composition of LiBH4-Ca(BH4)2 (LC) infiltrated into mesoporous scaffolds and the interface effect of various scaffolds. Eutectic melting and the melt infiltration of mixed borohydrides were observed through in situ NMR. In situ and ex situ NMR results for LC mixed with mesoporou...

1. de Waard-van der Spek FB, Mulder PG, Oranje AP. Prilocaine/lidocaine patch as a local premedication for skin biopsy in children. J Am Acad Dermatol. 1997; 37(3, pt 1):418-421. 2. Buckley MM, Benfield P. Eutectic lidocaine/prilocaine cream: a review of the topical anaesthetic/analgesic efficacy of a eutectic mixture of local anaesthetics (EMLA). Drugs. 1993;46(1):126-151. 3. Hoss DM, Gross EG...

OBJECTIVE We set out to compare a eutectic mixture of local anesthetic cream (lidocaine and prilocaine) to dorsal penile nerve block with lidocaine for anesthesia during circumcision. STUDY DESIGN In a double-blind study, term newborns were randomized to local anesthetic cream and sodium chloride solution dorsal penile nerve block (n = 31) or to placebo cream and lidocaine dorsal penile nerve...

Correction for 'Polymer-enforced crystallization of a eutectic binary hard sphere mixture' by Anna Kozina et al., Soft Matter, 2012, 8, 627-630.

The aim of present study were to arrest the problem of content uniformity without the use of harmful organic solvent and to improve ex vivo permeability of captopril, a low dose class III drug as per biological classification system. Eutectic mixture of camphor and menthol was innovatively used in the work. Captopril solution in eutectic mixture was blended with Avicel PH 102 and then the mixtu...

DESCRIPTION Oraqix (lidocaine and prilocaine periodontal gel,) 2.5%/2.5% is a microemulsion in which the oil phase is a eutectic mixture of lidocaine and prilocaine in a ratio of 1:1 by weight. This eutectic mixture has a melting point below room temperature, therefore both local anesthetics exist as liquid oils rather than as crystals. Oraqix contains poloxamer excipients, which show reversibl...